In Greek mythology, Klothó was the Fate who spun the thread of life. Science has since discovered her namesake — the Klothó Youth Protein — a longevity protein naturally present in skin that declines with age.
KLOTHÓ Rejuvenating Face Serum by AGNODICE is built around one mission: reactivating it.
At its heart, Lakesis oil® (Mastiha) — derived from the crystal tears of the Mastic tree, collected exclusively on the island of Chios, Greece — clinically recognized for awakening the Klothó Youth Protein. Paired with Kozanis Red Saffron infused in extra virgin Greek olive oil, both PDO-protected ingredients of Greece, and a full complex of Greek botanical oils and modern actives, KLOTHÓ by AGNODICE delivers what mature skin needs most — firmness, radiance, and a restored barrier — in a lightweight, deeply absorbing oil serum that melts into skin without a trace.
Ancient Greek wisdom. Modern skin science. One anti-aging face serum.
KLOTHÓ Anti-Aging Face Serum with Lakesis®(Mastiha) & Saffron
- Reactivates the Klothó Youth Protein with Lakesis® — mastiha's most concentrated, bioavailable form
- Visibly firms and supports elasticity with Collageneer® and Kozanis Red Saffron
- Brightens and evens skin tone for a radiant, luminous glow
- Supports skin renewal and smooths the appearance of fine lines with dual-source Vitamin A — from Rosehip Oil and Vitamin A Palmitate
- Deeply nourishes and restores the skin's lipid barrier without heaviness
- Absorbs beautifully — silky, non-greasy, and comfortable all day
• Lakesis Ol® (Pistacia Lentiscus): Derived from the crystallized resin — known as "crystal tears" — collected from the Mastic tree, native exclusively to the island of Chios, Greece. The most concentrated, bioavailable expression of mastiha resin. Clinically recognized for reactivating the Klothó Youth Protein, a longevity protein naturally present in skin that declines with age. The anchor of KLOTHÓ's anti-aging performance.
• Mastiha Oil (Chios): A lipid-rich blend carrying Pistacia Lentiscus Resin Extract — mastiha resin in its whole, unrefined form — in a base of Greek olive and sunflower oils. Where Lakesis® delivers concentrated, targeted activation of the Klothó Youth Protein, Mastiha Oil reinforces the skin barrier and delivers broad antioxidant protection.
• Kozanis Red Saffron infused in extra virgin Greek olive oil: Both ingredients carry PDO status — among the most protected designations in Greece. Naturally rich in crocin and safranal, powerful antioxidants known to brighten, enhance radiance, and support an even complexion. The olive oil base deepens absorption and nourishes at every layer.
• Collageneer® (Lupinus Albus Seed Extract): A patented, upcycled active, derived from sweet white lupine seed coating — zero waste by design. Clinically shown to support the skin's natural collagen synthesis for visibly firmer, more resilient skin.
• Abysoft® (Crambe Abyssinica Seed Oil Phytosterol Esters): Derived from the resilient Abyssinian plant. An advanced botanical phytosterol ester that wraps skin in a lightweight protective veil — the source of KLOTHÓ's signature silky, non-greasy finish.
• Maracuja (Passiflora Edulis) Seed Oil: Rich in linoleic acid and skin-essential fatty acids — lipids that mature skin loses over time. Deeply nourishes, helps restore the skin's barrier, and shields against environmental stressors, delivering a hydrated, luminous glow without heaviness.
• Rice Bran Oil (Oryza Sativa): Rich in antioxidants, phytosterols, and gamma-oryzanol — a compound unique to rice bran with recognized brightening and pigmentation-evening properties. Works alongside Abysoft® on the phytosterol pathway to boost hydration, smooth fine lines, and support a visibly more even, radiant complexion.
• Yarrow Extract (Achillea Millefolium): Named after Achilles — the Greek hero said to have used yarrow to heal his warriors' wounds. A fitting botanical for AGNODICE. Helps refine pores, balance the complexion, and soothe the skin with quiet, botanical precision.
After cleansing, apply your AGNODICE Hyaluronic Face Serum to damp skin, follow with moisturizer, then press 1-2 drops of KLOTHÓ by AGNODICE into face as the final step (2-3 drops if extending to neck). In the morning finish with SPF.
Oryza Sativa (Ricebran) Oil*, Passiflora Edulis (Passionfruit) Seed Oil*, Helianthus Annuus (Sunflower) Seed Oil*, Jojoba Esters, Rosa Canina Oil, Crambe Abyssinica Seed Oil Phytosterol Esters, Caprylic/Capric Triglyceride, Olea Europaea (Olive) Fruit Oil** and Crocus Sativus Stigma Extract, Achillea Millefolium (Yarrow) Extract, Vitamin A Palmitate, Helianthus Annuus (Sunflower) Seed Oil (and) Lupinus Albus Seed Extract, Mastiha Oil (Helianthus Annuus (Sunflower) Seed Oil, Olea Europaea Fruit Oil, Pistacia Lentiscus Resin Extract), Tocopherol, Cinnamomum Camphora CT Linalol, Caprylic/Capric Triglyceride (and) Pistacia Lentiscus (Mastic) Gum***
*organic origin
**Kozanis Red Saffron infused in extra virgin Greek olive oil***Lakesis — obtained by supercritical CO₂ extraction from the crystal tears collected on Pistacia Lentiscus, a tree native to the island of Chios, Greece
Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
Q: What does KLOTHÓ Rejuvenating Face Serum by AGNODICE do?
A: KLOTHÓ Rejuvenating Face Serum by AGNODICE is a Greek-inspired anti-aging face serum formulated to visibly improve skin radiance, softness, and elasticity. It features Lakesis® (Mastiha Tears of Chios) — reactivating the Klothó Youth Protein, combined with Kozanis Red Saffron infused in extra virgin Greek olive oil and antioxidant-rich Greek botanical oils to firm, nourish, and protect against the visible signs of aging.
Q: Is this serum suitable for mature skin?
A: Yes. KLOTHÓ by AGNODICE was formulated specifically for mature skin. Its hero ingredient, Lakesis oil®, works to reactivate the Klothó Youth Protein — a longevity protein naturally found in the skin that declines with age. Combined with Kozanis Red Saffron infused in extra virgin Greek olive oil and nourishing Greek botanical oils, KLOTHÓ by AGNODICE supports elasticity, firmness, and radiance in a way that generic serums cannot.
Q: Is oil-based skincare good for aging-skin?
A: Yes — and it's one of the most effective approaches for mature skin. As skin ages, it loses lipids and struggles to retain moisture. Oil-based serums like KLOTHÓ by AGNODICE replenish those lipids, reinforce the skin barrier, and deliver fat-soluble actives deeper into the skin. KLOTHÓ by AGNODICEcombines Greek botanical oils with modern targeted actives, including Lakesis and Kozanis Red Saffron infused in extra virgin Greek olive oil, to support long-term skin health — bridging ancient Greek botanical wisdom with contemporary formulation science.
Q: How do you use AGNODICE KLOTHÓ Rejuvenating Face Serum?
A: After cleansing, apply your AGNODICE Hyaluronic Face Serum first, then follow with KLOTHÓ by AGNODICE. Apply 2–3 drops to the palms and gently press into the face, neck, and décolleté. In the morning, finish with your moisturizer and SPF. KLOTHÓ by AGNODICE is designed to be the final active step before sun protection, allowing its Greek botanical oils and targeted actives to fully absorb.
Q: Can I use this with other skincare products?
A: Yes. KLOTHÓ by AGNODICE is designed to layer seamlessly within your skincare routine. It pairs especially well with the AGNODICE Hyaluronic Face Serum — apply the hyaluronic serum first to hydrate, then press KLOTHÓ by AGNODICE over it to seal in moisture and deliver its botanical actives. It can also be used alone as a nourishing treatment for the face, neck, and décolleté.
Q: What makes this serum different?
A: KLOTHÓ by AGNODICE is unlike conventional anti-aging serums because it is rooted in both Greek botanical heritage and modern skin science. Its anchor ingredient, Lakesis® is an oil derived from the crystal tears of the Mastic tree — collected exclusively on the island of Chios, Greece — and clinically recognized for reactivating the Klothó Youth Protein. Paired with Kozanis Red Saffron infused in extra virgin Greek olive oil — both PDO-protected Greek ingredients — and no synthetic fragrance or unnecessary fillers, KLOTHÓ embodies the AGNODICE philosophy: purity, simplicity, and restoring what time has changed.
Q: What is Collageneer® (lupine extract) in AGNODICE skincare?
A: Collageneer® is a patented, upcycled active derived from sweet white lupine seed coating — zero waste by design. Included in KLOTHÓ Rejuvenating Face Serum by AGNODICE to support the skin's natural collagen production, it works alongside Lakesis oil® and Kozanis Red Saffron infused in extra virgin Greek olive oil to visibly firm skin and reduce the appearance of fine lines — a modern active rooted in the same philosophy of purposeful, results-driven formulation that defines AGNODICE.Q: How can I improve skin elasticity naturally?
A: Skin elasticity naturally declines with age as collagen and lipid production slow down. KLOTHÓ Rejuvenating Face Serum by AGNODICE addresses this with a combination of Lakesis® — reactivating the Klothó Youth Protein — Collageneer® lupine extract to support collagen synthesis, Kozanis Red Saffron infused in extra virgin Greek olive oil, and Greek botanical oils that replenish the lipids mature skin loses over time. This is AGNODICE's approach: ancient Greek botanical intelligence paired with modern skin science to restore what time has changed.
Reviews
This product is amazing! It is so smooth and melts into my skin and last all day and very hydrating. Will order more!
Love the silky feel of this serum and how it brightens my skin complexion! My skin looks younger and feels smooth and refreshed!